97 genes with Melanoma Phenotype Specific Expression

Back in 2006 we published a list of 105 genes which showed melanoma phenotype specific expression. This was based on an analysis of three different libraries of melanoma cell gene expression data (Hoek et al., 2006). In 2012 we updated the analysis, using a total of six different libraries of data, and identified 97 MPSE genes (Widmer et al., 2012). From the old list we retained 46 genes.

These genes represent the hard core MPSE set because they undergo the largest and most significant changes in expression between phenotypes. As such they are most useful for discriminating between phenotypes by gene expression (see HOPP). However, many other genes also have expression patterns which are significantly linked to phenotype. You may wish to explore whether or not a gene you are interested in has such a relationship by going to the HOPP MPSE Facility.

The numbers in the "Proliferative" and "Invasive" columns refer to standardized expression values which are used in the phenotype prediction algorithm HOPP.

Probe setSymbolTitleProliferativeInvasivePhenotype
222294_s_at------16.6754.442Proliferative
204638_atACP5acid phosphatase 5, tartrate resistant16.943.8275Proliferative
213217_atADCY2adenylate cyclase 2 (brain)4.2630.6735Proliferative
203382_s_atAPOEapolipoprotein E16.022.211Proliferative
203381_s_atAPOEapolipoprotein E25.5152.787Proliferative
213902_atASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 136.0211.03Proliferative
210980_s_atASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 183.56523.32Proliferative
213702_x_atASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1109.3539.19Proliferative
220451_s_atBIRC7baculoviral IAP repeat-containing 712.5751.65Proliferative
220941_s_atC21orf91chromosome 21 open reading frame 916.6691.6525Proliferative
211890_x_atCAPN3calpain 3, (p94)42.321.4Proliferative
214475_x_atCAPN3calpain 3, (p94)47.4950.9265Proliferative
201131_s_atCDH1cadherin 1, type 1, E-cadherin (epithelial)1.3790.214Proliferative
211804_s_atCDK2cyclin-dependent kinase 240.0856.9255Proliferative
204252_atCDK2cyclin-dependent kinase 264.43515.03Proliferative
204995_atCDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)4.75751.076Proliferative
209498_atCEACAM1carcinoembryonic antigen-related cell adhesion molecule 111.0151.3005Proliferative
203139_atDAPK1death-associated protein kinase 18.59552.7345Proliferative
216513_atDCTdopachrome tautomerase8.8930.607Proliferative
216512_s_atDCTdopachrome tautomerase91.091.1255Proliferative
205337_atDCTdopachrome tautomerase105.850.666Proliferative
205338_s_atDCTdopachrome tautomerase122.31.3885Proliferative
51158_atFAM174Bfamily with sequence similarity 174, member B2.5650.8455Proliferative
203397_s_atGALNT3UDP-N-acetyl- -D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 39.40.3305Proliferative
212959_s_atGNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits33.7412.87Proliferative
209169_atGPM6Bglycoprotein M6B15.0351.173Proliferative
209168_atGPM6Bglycoprotein M6B17.4151.9235Proliferative
209167_atGPM6Bglycoprotein M6B59.384.4745Proliferative
209170_s_atGPM6Bglycoprotein M6B76.96.255Proliferative
206696_atGPR143G protein-coupled receptor 14330.9050.711Proliferative
203632_s_atGPRC5BG protein-coupled receptor, family C, group 5, member B18.0654.647Proliferative
210964_s_atGYG2glycogenin 211.441.197Proliferative
54037_atHPS4Hermansky-Pudlak syndrome 47.3892.132Proliferative
218402_s_atHPS4Hermansky-Pudlak syndrome 410.463.1065Proliferative
205376_atINPP4Binositol polyphosphate-4-phosphatase, type II, 105kDa22.0356.794Proliferative
204562_atIRF4interferon regulatory factor 49.81151.59Proliferative
201362_atIVNS1ABPinfluenza virus NS1A binding protein21.4558.854Proliferative
213478_atKAZkazrin16.15.269Proliferative
207323_s_atMBPmyelin basic protein19.691.692Proliferative
209072_atMBPmyelin basic protein60.561.401Proliferative
218376_s_atMICAL1microtubule associated monoxygenase, calponin and LIM domain containing 111.9753.966Proliferative
207233_s_atMITFmicrophthalmia-associated transcription factor104.358.1345Proliferative
206426_atMLANAmelan-A74.9250.524Proliferative
206427_s_atMLANAmelan-A187.60.687Proliferative
212338_atMYO1Dmyosin ID7.4381.554Proliferative
207978_s_atNR4A3nuclear receptor subfamily 4, group A, member 34.1510.831Proliferative
209959_atNR4A3nuclear receptor subfamily 4, group A, member 38.42551.4925Proliferative
206498_atOCA2oculocutaneous albinism II11.651.2525Proliferative
213638_atPHACTR1phosphatase and actin regulator 126.652.1535Proliferative
207469_s_atPIRpirin (iron-binding nuclear protein)66.8312.785Proliferative
206470_atPLXNC1plexin C14.3040.6245Proliferative
206471_s_atPLXNC1plexin C14.76850.477Proliferative
213241_atPLXNC1plexin C124.8251.1Proliferative
209848_s_atPMELPremelanosome protein246.951.1995Proliferative
209515_s_atRAB27ARAB27A, member RAS oncogene family37.7059.7065Proliferative
219412_atRAB38RAB38, member RAS oncogene family56.497.02Proliferative
210138_atRGS20regulator of G-protein signaling 2010.2853.3555Proliferative
212122_atRHOQras homolog gene family, member Q11.2854.0495Proliferative
212119_atRHOQras homolog gene family, member Q56.23522.075Proliferative
221523_s_atRRAGDRas-related GTP binding D11.632.598Proliferative
221524_s_atRRAGDRas-related GTP binding D37.7758.878Proliferative
215028_atSEMA6Asema domain, transmembrane domain, and cytoplasmic domain, 6A1.94750.298Proliferative
202896_s_atSIRPAsignal-regulatory protein alpha10.8154.349Proliferative
202897_atSIRPAsignal-regulatory protein alpha14.5554.726Proliferative
221644_s_atSLC45A2solute carrier family 45, member 223.1450.498Proliferative
220245_atSLC45A2solute carrier family 45, member 237.721.332Proliferative
210942_s_atST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 621.4653.4385Proliferative
212631_atSTX7syntaxin 719.0955.9865Proliferative
209354_atTNFRSF14tumor necrosis factor receptor superfamily, member 1413.192.4515Proliferative
206479_atTRPM1transient receptor potential cation channel, subfamily M, member 11.1880.2095Proliferative
206630_atTYRtyrosinase133.851.8765Proliferative
205694_atTYRP1tyrosinase-related protein 173.230.745Proliferative
218971_s_atWDR91WD repeat domain 917.6993.332Proliferative
203651_atZFYVE16zinc finger, FYVE domain containing 1619.945.565Proliferative
213790_atADAM12ADAM metallopeptidase domain 120.35451.387Invasive
202952_s_atADAM12ADAM metallopeptidase domain 120.5913.175Invasive
203002_atAMOTL2angiomotin like 24.55411.315Invasive
202686_s_atAXLAXL receptor tyrosine kinase0.822527.955Invasive
210538_s_atBIRC3baculoviral IAP repeat-containing 30.25151.141Invasive
204726_atCDH13cadherin 13, H-cadherin (heart)0.1662.12Invasive
204604_atCDK14cyclin-dependent kinase 142.1686.3055Invasive
211343_s_atCOL13A1collagen, type XIII, alpha 10.3054.8645Invasive
202552_s_atCRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.8277.5345Invasive
202551_s_atCRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)1.324515.83Invasive
221541_atCRISPLD2cysteine-rich secretory protein LCCL domain containing 20.76252.0775Invasive
210764_s_atCYR61cysteine-rich, angiogenic inducer, 612.25521.695Invasive
201289_atCYR61cysteine-rich, angiogenic inducer, 613.58935.96Invasive
204646_atDPYDdihydropyrimidine dehydrogenase0.39656.108Invasive
201842_s_atEFEMP1EGF-containing fibulin-like extracellular matrix protein 10.4298.129Invasive
201983_s_atEGFRepidermal growth factor receptor0.48253.8605Invasive
213506_atF2RL1coagulation factor II (thrombin) receptor-like 10.19351.327Invasive
204421_s_atFGF2fibroblast growth factor 2 (basic)1.13953.1335Invasive
208614_s_atFLNBfilamin B, beta3.146511.825Invasive
206307_s_atFOXD1forkhead box D13.384510.725Invasive
204948_s_atFSTFollistatin2.49512.765Invasive
210220_atFZD2frizzled homolog 2 (Drosophila)1.3875.4265Invasive
212822_atHEG1HEG homolog 1 (zebrafish)3.2169.145Invasive
213069_atHEG1HEG homolog 1 (zebrafish)5.84418.235Invasive
219985_atHS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A10.2681.668Invasive
205032_atITGA2integrin, alpha 21.3374.5465Invasive
201474_s_atITGA3integrin, alpha 32.3648.88Invasive
221583_s_atKCNMA1potassium large conductance calcium-activated channel M alpha 10.24251.497Invasive
221584_s_atKCNMA1potassium large conductance calcium-activated channel M alpha 10.5867.361Invasive
202998_s_atLOXL2lysyl oxidase-like 22.12450.455Invasive
211864_s_atMYOFmyoferlin7.40726.005Invasive
212298_atNRP1neuropilin 10.26616.01Invasive
210510_s_atNRP1neuropilin 10.74857.023Invasive
222020_s_atNTMneurotrimin0.63053.9455Invasive
204589_atNUAK1NUAK family, SNF1-like kinase, 11.2114.0785Invasive
205729_atOSMRoncostatin M receptor0.94456.1405Invasive
218718_atPDGFCplatelet derived growth factor C1.39613.08Invasive
201578_atPODXLpodocalyxin-like0.8256.537Invasive
204268_atS100A2S100 calcium binding protein A21.40253.8375Invasive
205896_atSLC22A4solute carrier family 22, member 40.58051.9755Invasive
209897_s_atSLIT2slit homolog 21.03653.6665Invasive
210612_s_atSYNJ2synaptojanin 20.9763.196Invasive
212382_atTCF4transcription factor 40.3581.605Invasive
203753_atTCF4transcription factor 40.4022.848Invasive
213891_s_atTCF4transcription factor 40.433.315Invasive
201110_s_atTHBS1thrombospondin 10.831524.895Invasive
201109_s_atTHBS1thrombospondin 11.04842.19Invasive
216997_x_atTLE4transducin-like enhancer of split 40.19850.888Invasive
204872_atTLE4transducin-like enhancer of split 40.8535.4715Invasive
204932_atTNFRSF11Btumor necrosis factor receptor superfamily, member 11b0.20451.108Invasive
203476_atTPBGtrophoblast glycoprotein1.084517.96Invasive
206116_s_atTPM1tropomyosin 1 (alpha)7.633551.005Invasive
210987_x_atTPM1tropomyosin 1 (alpha)12.58583.55Invasive
210986_s_atTPM1tropomyosin 1 (alpha)18.3599.125Invasive
202369_s_atTRAM2translocation associated membrane protein 212.50527.435Invasive
213425_atWNT5Awingless-type MMTV integration site family, member 5A0.2847.6665Invasive
205990_s_atWNT5Awingless-type MMTV integration site family, member 5A0.63120.68Invasive
210875_s_atZEB1zinc finger E-box binding homeobox 10.2482.0565Invasive
212764_atZEB1zinc finger E-box binding homeobox 10.5168.2985Invasive
212758_s_atZEB1zinc finger E-box binding homeobox 10.7963.4985Invasive