Mitf target genes

This is a list of 141 genes identified by us and others to be positively regulated by Mitf.

Note, this list is specific for Mitf regulation in a melanocytic context!

SymbolNameReference
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2Hoek et al., 2008
ACP5Acid phosphatase 5, tartrate resistantLuchin et al., 2000
ACSL1Acyl-CoA synthetase long-chain family member 1Hoek et al., 2008
AMDHD2Amidohydrolase domain containing 2Hoek et al., 2008
APOEApolipoprotein EHoek et al., 2008
APOLD1Apolipoprotein L domain containing 1Hoek et al., 2008
ARMC9armadillo repeat containing 9Hoek et al., 2008
ASAH1N-acylsphingosine amidohydrolase 1Hoek et al., 2008
ATOX1ATX1 antioxidant protein 1 homolog (yeast)Hoek et al., 2008
ATP10AATPase, class V, type 10AHoek et al., 2008
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1Hoek et al., 2008
BCANbrevicanHoek et al., 2008
BCL2B-cell CLL / lymphoma 2McGill et al., 2002
BCL2A1BCL2-related protein A1Hoek et al., 2008
BDH13-hydroxybutyrate dehydrogenase, type 1Hoek et al., 2008
BEST1Bestrophin 1Esumi et al., 2007
BIRC7Baculoviral IAP repeat-containing 7Dynek et al., 2008
C14orf109Chromosome 14 open reading frame 109Hoek et al., 2008
C19orf28chromosome 19 open reading frame 28Hoek et al., 2008
CA14Carbonic anhydrase XIVHoek et al., 2008
CAPGcapping protein (actin filament), gelsolin-likeHoek et al., 2008
CAPN3Calpain 3Hoek et al., 2008
CBR3carbonyl reductase 3Hoek et al., 2008
CDK2Cyclin-dependent kinase 2Du et al., 2004
CDK5R1Cyclin-dependent kinase 5, regulatory subunit 1 (p35)Hoek et al., 2008
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1Hoek et al., 2008
CHKACholine kinase alphaHoek et al., 2008
CHL1cell adhesion molecule with homology to L1CAMHoek et al., 2008
CLCN7Chloride channel 7Meadows et al., 2007
CPEB1cytoplasmic polyadenylation element binding protein 1Hoek et al., 2008
CPN1carboxypeptidase N, polypeptide 1Hoek et al., 2008
CYP27A1cytochrome P450, family 27, subfamily A, polypeptide 1Hoek et al., 2008
DCTDopachrome tautomeraseYasumoto et al., 2002
DUSP4dual specificity phosphatase 4Hoek et al., 2008
DYNC1I1dynein, cytoplasmic 1, intermediate chain 1Hoek et al., 2008
EDNRBEndothelin receptor type BSato-Jin et al., 2007
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)Hoek et al., 2008
ETV5ets variant gene 5 (ets-related molecule)Hoek et al., 2008
FABP7fatty acid binding protein 7, brainHoek et al., 2008
FAIM3Fas apoptotic inhibitory molecule 3Hoek et al., 2008
FAM53BFamily with sequence similarity 53, member BHoek et al., 2008
FRMD4BFERM domain containing 4BHoek et al., 2008
FXYD3FXYD domain containing ion transport regulator 3Hoek et al., 2008
GAB2GRB2-associated binding protein 2Hoek et al., 2008
GCNT2glucosaminyl (N-acetyl) transferase 2, I-branching enzymeHoek et al., 2008
GJB1gap junction protein, beta 1, 32kDaHoek et al., 2008
GM2AGM2 ganglioside activatorHoek et al., 2008
GMPRGuanosine monophosphate reductaseHoek et al., 2008
GNPTABN-acetylglucosamine-1-phosphate transferase a and bHoek et al., 2008
GPM6BGlycoprotein M6BHoek et al., 2008
GPNMBGlycoprotein (transmembrane) nmbLoftus et al., 2008
GPR137BG protein-coupled receptor 137BHoek et al., 2008
GPR143G protein-coupled receptor 143 (Oa1)Vetrini et al., 2004
GPR56G protein-coupled receptor 56Hoek et al., 2008
GREB1GREB1 proteinHoek et al., 2008
GYG2Glycogenin 2Hoek et al., 2008
GYPCglycophorin C (Gerbich blood group)Hoek et al., 2008
HPGDHydroxyprostaglandin dehydrogenase 15-(NAD)Hoek et al., 2008
HPS4Hermansky-Pudlak syndrome 4Hoek et al., 2008
IL16interleukin 16 (lymphocyte chemoattractant factor)Hoek et al., 2008
IL6RInterleukin 6 receptorHoek et al., 2008
INPP4BInositol polyphosphate-4-phosphatase, type IIHoek et al., 2008
IRF4Interferon regulatory factor 4Hoek et al., 2008
ITPKBInositol 1,4,5-trisphosphate 3-kinase BHoek et al., 2008
IVNS1ABPInfluenza virus NS1A binding proteinHoek et al., 2008
KCNAB2potassium voltage-gated channel, shaker-related subfamily, beta member 2Hoek et al., 2008
KCNN2Potassium calcium-activated channel N2Hoek et al., 2008
KIAA1026KazrinHoek et al., 2008
KIAA1598KIAA1598Hoek et al., 2008
LDB3LIM domain binding 3Hoek et al., 2008
LEF1lymphoid enhancer-binding factor 1Hoek et al., 2008
LGALS3Lectin, galactoside-binding, soluble, 3Hoek et al., 2008
LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinHoek et al., 2008
LYSTLysosomal trafficking regulatorHoek et al., 2008
LZTS1leucine zipper, putative tumor suppressor 1Hoek et al., 2008
MBPMyelin basic proteinHoek et al., 2008
MC1RMelanocortin 1 receptorAoki and Moro, 2002
MICAL1Microtubule-associated monoxygenase calponin / LIM containing 1Hoek et al., 2008
MLANAMelan-ADu et al., 2003
MLPHmelanophilinHoek et al., 2008
MMP17matrix metallopeptidase 17 (membrane-inserted)Hoek et al., 2008
MTHFS5,10-methenyltetrahydrofolate synthetaseHoek et al., 2008
NAV2neuron navigator 2Hoek et al., 2008
OSTM1Osteopetrosis-associated transmembrane protein 1Meadows et al., 2007
P2RX7purinergic receptor P2X, ligand-gated ion channel, 7Hoek et al., 2008
PHACTR1Phosphatase and actin regulator 1Hoek et al., 2008
PIRPirinHoek et al., 2008
PLA1APhospholipase A1 member AHoek et al., 2008
PLP1proteolipid protein 1Hoek et al., 2008
PSEN2Presenilin 2Hoek et al., 2008
QDPRQuinoid dihydropteridine reductaseHoek et al., 2008
RAB17RAB17, member RAS oncogene familyHoek et al., 2008
RAB27ARAB27A, member RAS oncogene familyChiaverini et al., 2008
RAB32RAB32, member RAS oncogene familyHoek et al., 2008
RAB38RAB38, member RAS oncogene familyHoek et al., 2008
RBM35ARNA-binding motif protein 35AHoek et al., 2008
RGS20regulator of G-protein signaling 20Hoek et al., 2008
RHOQRas homolog gene family, member QHoek et al., 2008
RIPK5Receptor interacting protein kinase 5Hoek et al., 2008
ROPN1Bropporin, rhophilin associated protein 1BHoek et al., 2008
RRAGDRas-related GTP binding DHoek et al., 2008
RTP4receptor (chemosensory) transporter protein 4Hoek et al., 2008
RUNX3runt-related transcription factor 3Hoek et al., 2008
S100A1S100 calcium binding protein A1Hoek et al., 2008
SCUBE2signal peptide, CUB domain, EGF-like 2Hoek et al., 2008
SEMA6ASemaphorinHoek et al., 2008
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)Hoek et al., 2008
SGK3Serum / glucocorticoid regulated kinase family, member 3Hoek et al., 2008
SILVSilver homolog (mouse)Du et al., 2003
SIRPAsignal-regulatory protein alphaHoek et al., 2008
SLC16A6solute carrier family 16, member 6 (monocarboxylic acid transporter 7)Hoek et al., 2008
SLC1A4Solute carrier family 1, member 4Hoek et al., 2008
SLC27A3solute carrier family 27 (fatty acid transporter), member 3Hoek et al., 2008
SLC45A2Solute carrier family 45, member 2Du and Fisher, 2002
SLC7A8Solute carrier family 7, member 8Hoek et al., 2008
SNCAsynuclein, alpha (non A4 component of amyloid precursor)Hoek et al., 2008
SORT1Sortilin 1Hoek et al., 2008
SOX10SRY (sex determining region Y)-box 10Hoek et al., 2008
SOX13SRY (sex determining region Y)-box 13Hoek et al., 2008
SPSB1splA/ryanodine receptor domain and SOCS box containing 1Hoek et al., 2008
ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6Hoek et al., 2008
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1Hoek et al., 2008
STX7Syntaxin 7Hoek et al., 2008
STXBP1Syntaxin binding protein 1Hoek et al., 2008
TBC1D16TBC1 domain family, member 16Hoek et al., 2008
TBX2T-box 2Carreira et al., 2000
TDRD7Tudor domain containing 7Hoek et al., 2008
TIMP2TIMP metallopeptidase inhibitor 2Hoek et al., 2008
TMC6Transmembrane channel-like 6Hoek et al., 2008
TMCC2Transmembrane and coiled-coil domain family 2Hoek et al., 2008
TMEM51transmembrane protein 51Hoek et al., 2008
TNFRSF14Tumor necrosis factor receptor superfamily 14Hoek et al., 2008
TRIB2tribbles homolog 2 (Drosophila)Hoek et al., 2008
TRIM2tripartite motif-containing 2Hoek et al., 2008
TRPM1Transient receptor potential cation channel, M1Miller et al., 2004
TYRTyrosinaseHou et al., 2000
TYRP1Tyrosinase-related protein 1Fang et al., 2002
USP48Ubiquitin specific peptidase 48Hoek et al., 2008
VAT1Vesicle amine transport protein 1Hoek et al., 2008
WIPI1WD repeat domain, phosphoinositide interacting 1Hoek et al., 2008
ZFYVE16Zinc finger, FYVE domain containing 16Hoek et al., 2008